What’s the cost of a flight from Chicago to Santa Cruz de la Sierra?

Prices vary based on date, airline, and availability. Compare several options if you're flying between Chicago and Santa Cruz.

Choose a date to explore the best fares now.

If possible, avoid holiday periods: ticket prices tend to rise quickly and availability drops, especially on busy routes. Morning and evening flights are often in high demand too — book early to get a good fare.

Which departure and arrival airports are available?

Between Chicago and Santa Cruz, flight options may depend on the combination of airports available.

• Airports in Chicago: Chicago is connected by 3 airports - Midway, O'Hare, Rockford.
• Airports in Santa Cruz: Another alternative is Santa Cruz.

Sometimes flying into a nearby city can be more cost-effective. When a city has multiple airports, it’s worth comparing different flight combinations.

Adjust your flight filters for Chicago – Santa Cruz de la Sierra

Jetcost gives you tools to search smarter. Pick your ideal price range, airline, departure time, and flight type — then compare offers from the best travel agencies and carriers.

Other popular destinations

Planning a trip to Bolivia? These cities are popular too: Cochabamba, La Paz, Quijarro, Santa Cruz, Sucre.

Sorting options let you see the most affordable flights first. Some results may include extra fees shown only at checkout — always read carefully to see what’s included.